Exemestane

Exemestane is an effective antiestrogen, which is a powerful aromatase inhibitor. It is used both in traditional medicine, for which it was originally developed, and in sports practice.

Exemestane is used in bodybuilding and sports in general mainly by athletes taking anabolic and androgenic steroids. It is used mainly during heavy steroid cycles, as an adjuvant, in order to prevent the development of estrogenic side effects or to eliminate them.

Exemestane

In turn, in medicine, it is prescribed mainly in the treatment of breast cancer in women or in the treatment of its symptoms to reduce risks.

Exemestane tablets: description

This antiestrogen is an irreversible steroidal aromatase inhibitor similar in structure to the natural substance androstenedione. It belongs to the third generation of aromatase enzyme blockers, which are regularly used today for the treatment of various diseases (mainly in oncology). The third generation also includes antiestrogenic agents such as anastrozole and letrozole.

Exemestane tablets: description

For athletes, the effect of exemestane is also significant, which consists in a slight increase in the concentration of FSH and LH in the blood serum. This improvement, presumably, develops at the level of the pituitary gland on a feedback principle, when a decrease in estrogen stimulates the secretion of gonadotropic hormones and, as a result, testosterone.

It is important to note that exemestane, as an antiestrogen drug, does not have estrogenic or progestogenic activity. Only a small androgenic activity was detected, which is observed mainly when using high dosages.

This antiestrogen, used in tablets, has no effect on the synthesis of aldosterone and cortisol in the adrenal glands, which confirms the selectivity of its effect.

Effects of Aromasin (Exemestane)

  • Prevention of gynecomastia
  • Decreased estrogen production (by 97%)
  • Increasing anabolic hormone levels
  • Improving the relief of muscles
  • Prevention of hypertension

Dosages and course of taking Aromasin (Exemestane)

  • For prevention (in bodybuilding): 12.5 mg every other day.
  • For the treatment of gynecomastia: 25 mg every day until symptoms disappear (then 12.5 mg every other day).

Taking a course of steroids:

  • When using steroids with a short half-life (testosterone propionate, methandrostenolone): after 10 days of the course, take an analysis for estradiol and take 12.5 mg of Aromasin (Exemestane) every other day. Then, after 10 days, once again take tests for estradiol and adjust the dosage of Aromasin (Exemestane) according to their results.
  • When using steroids with long esters (enanthate, sustanon, cypionate): after 3-4 weeks of the course, take tests for estradiol and take 12.5 mg of Aromasin (Exemestane) every other day. Then, after 10 days, once again take tests for estradiol and adjust the dosage of Aromasin (Exemestane) according to their results.

Like other aromatase inhibitors, the dosage of Aromasin can be adjusted according to subjective feelings. If depression, a drop in libido and erectile dysfunction are observed while taking Aromasin (Exemestane), the dosage should be reduced.

Exemestane in bodybuilding

This antiestrogen for sports purposes, in particular in bodybuilding, is used mainly during heavy steroid cycles. For use in sports, it is recommended primarily for athletes who are worried about the risk of estrogenic side effects such as gynecomastia, or who are already experiencing symptoms.

Exemestane in bodybuilding

If the use of exemestane is carried out by an athlete for prophylactic purposes in order to avoid the risk of side effects, then, as a rule, a dosage of about 12.5-25 mg per day or every other day (half a tablet a day or a tablet every other day) is recommended. In turn, if the intake takes place already with the appearance of deviations, then a dosage of 25 mg per day should be used until all symptoms are eliminated.

Exemestane should be taken immediately after meals. Despite the fact that the absolute bioavailability of the drug has not been established, it is known for sure that food intake increases its bioavailability by 40%. The drug is excreted mainly with feces and urine in equal proportions (about 40%) during the week, and only from 0.1% to 1% is excreted unchanged. The terminal half-life is about 24 hours.

Side effects of Aromasin (Exemestane)

Exceeding dosages and abuse of aromatase inhibitors leads to excessive suppression of estrogen production and the following effects:

Side effects of Aromasin (Exemestane)
  • Inhibition of muscle growth
  • Depression
  • Drop in libido
  • Increasing cholesterol levels
  • Joint pain
  • Decreased bone strength

Side effects of Aromasin (Exemestane):

hot flush:

  • Nausea
  • Increased risk of fractures (by 60%)
  • Joint pain
  • Formation of arterial and venous thrombi
  • Dryness of the mucous membranes of the urogenital zone