Anastrozole is a medical drug, the action of which is aimed at reducing the amount of estrogen and increasing the production of testosterone in the body.

In the field of bodybuilding, Anastrozole has become widespread as a post-cycle therapy after taking strong anabolic steroids, due to its ability to effectively remove water and resist gynecomastia. The advantages of the drug also include a quick action: the aromatization processes are blocked within 2 days after the start of the intake.


Thanks to the use of this drug, the accumulation of water and fat during the steroid cycle is reduced.

It is because of this that athletes often abuse antiestrogen to compensate for poor nutrition or the consequences of an incorrect cycle of anabolic steroids.

Anastrozole in bodybuilding has gained popularity due to the fact that it purposefully suppresses the synthesis of estrogens in the body. That is, in fact, the drug eliminates the cause, and not the symptoms of estrogenic manifestations. Therefore, Anastrozole has a pronounced fat burning effect, since the formation of body fat also occurs under the influence of estrogens.

The use of Anastrozole in bodybuilding helps to successfully solve a number of problems:

  • prevent or treat gynecomastia in male athletes;
  • improve muscle relief;
  • increase the level of anabolic hormones;
  • prevent possible enlargement of the prostate due to steroids.

Dosages and course of taking Anastrozole

For prevention (in bodybuilding): 0.25 – 0.5 mg every 3-6 days

For the treatment of gynecomastia: 1 mg every day until the symptoms disappear (then 0.5 mg every other day).

The optimal course of Anastrozole when using steroids:

When using steroids with a short half-life (testosterone propionate, methandrostenolone): after 10 days of the course, take an analysis for estradiol and take 0.5 mg of Anastrozole every other day. Then, after 10 days, take another test for estradiol and adjust the dosage of Anastrozole according to their results.

When using steroids with long esters (enanthate, sustanon, cypionate): after 3-4 weeks of the course, take tests for estradiol and take 0.25-0.5 mg every 3-6 days of Anastrozole every other day. Then, after 10 days, take another test for estradiol and adjust the dosage of Anastrozole according to their results.

The optimal course of Anastrozole when using steroids:

It is recommended to start taking the drug simultaneously with the start of the course of anabolic steroids, or when signs of aromatization appear. Therefore, it is best to order steroids and Anastrozole in combination. The standard dosage is 0.25 – 1 mg. The drug is well absorbed regardless of food intake, but it has the greatest effect when taken on an empty stomach. In this case, it is well absorbed by the intestines and quickly enters the bloodstream.

The average dosage of the drug (0.50 mg) is indicated in order to prevent unwanted aromatization. Increasing the dose to 1 mg per day is necessary when signs of gynecomastia appear or when aromatizing steroids are taken in high doses.


Anastrozole side effects

Common side effects associated with the use of aromatase inhibitors include: hot flashes, joint pain, weakness, fatigue, mood swings, depression, high blood pressure, swelling of the arms/legs, and headache. Aromatase inhibitors can also lead to a decrease in bone mineral density, which can lead to the development of osteoporosis and increase the number of fractures in susceptible patients.

Some people may also experience side effects such as gastrointestinal problems, nausea, and vomiting. Aromatase inhibitors can harm fetal development and should not be used during pregnancy. When taken off-label by men to lower estrogen levels during long periods of steroid therapy, aromatase inhibitors may increase the risk of developing cardiovascular disease (CVD) by curbing the positive effects of estrogen on cholesterol levels.

Anastrozole side effects

Studies have shown that when steroids that tend to aromatize, such as testosterone enanthate, are combined with an aromatase inhibitor, there is more suppression of high-density lipoprotein (high-density lipoprotein, “good” cholesterol). Because the estrogen receptor agonist/antagonist Nolvadex generally does not have the same anti-estrogenic (negative) effect on cholesterol levels, it is generally preferred among male bodybuilders and athletes with cardiovascular problems than aromatase inhibitors.

With the standard regimen of taking Anastrozole, the occurrence of adverse reactions is excluded, so the course of the drug, if necessary, can be very long. Side effects of the drug in the form of allergic reactions, headache, diarrhea, nausea can occur only in case of overdose or individual intolerance.

For female athletes, taking Anastrozole is contraindicated, since the drug causes significant changes in the hormonal background, which can lead to irreversible negative consequences in the female body.